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Immunoglobulins and T Cell receptor Differences

The differences between immunoglobulins and T cell Receptors:

Ig are found on the membrane and can be secreted, T cell receptors are are only on the membrane.

2. Ig can bind to free antigen. TCR requires antigen presentation cells (APC) before it can bind.

3.Ig has two Ag binding sites (bivalent). TCR only has one antigen binding site (monovalent)

4. Ig can bind to protein, carbohydrates, lipids, nucleic acid Ag. TCR can only bind to peptide Ag in MHC binding region.


Here is a picture of BCR and TCR

Tcr and bcr



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