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The five antibody isotypes!

IgG : most abundant in serum, there are 4 types of them. IgG1-4. Differ in heavy region of heavy chains. Major part of secondary response


IgM: a pentamer with ten identical binding sites. It is an isotype predominant in primary response. First Ab secreted in primary response


IgA: predominent in body secretions, including mucus and breast milk. Secreted form is a dimer with 4 antigen binding sites. It is also resistant to proteases. Responsible for passive immunity in breast milk.


IgE: associated with allergic inflammation, can sensitive mast call and basophils.


IgD: not associated with an effector function, but express with IgM on surface of B cell. Can serve as a function in regulation B cell physiology.



I am a wandering soul! I enjoy traveling and adventure. I am mostly on WP to read stories from other fellow adventurers and improve my writing skills. I read to seek information and learn about life to understand more about human relations. Feel free to follow and comment :).

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